Erythropoietin and Neonatal Neuroprotection
نویسندگان
چکیده
منابع مشابه
Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke.
Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not been defined, and local changes in cell fate decision may play a role in functio...
متن کاملErythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics.
OBJECTIVE To determine the safety and pharmacokinetics of erythropoietin (Epo) given in conjunction with hypothermia for hypoxic-ischemic encephalopathy (HIE). We hypothesized that high dose Epo would produce plasma concentrations that are neuroprotective in animal studies (ie, maximum concentration = 6000-10000 U/L; area under the curve = 117000-140000 U*h/L). METHODS In this multicenter, op...
متن کاملP39: The Neuroprotection Effect of Erythropoietin in Cerebral Ischemia
Cerebral ischemia causes death of millions people all over the world, annually and also suffering more people from neurological deficits and neuromuscular disorders. In our country, 250 to 300 people experience mild to severe stroke, daily. In this study we reviewed 120 original paper selected from PubMED database. Our keywords were erythropoietin, anti-inflammatory, stroke, neuropathy and cere...
متن کاملNeuroprotection by Erythropoietin – A Review
Many hematopoietic growth factors are produced locally in the brain. Erythropoietin (EPO) is the principal growth factor regulating the production of red blood cells. Erythropoietin (EPO) isa glycoprotein hormone that acts as major regulator of erythropoiesis.Erythropoietin (EPO) has a dominant role for neuroprotection, neurogenesis and acting as neurotropic factor in the central nervous system...
متن کاملERYTHROPOIETIN AND THE NERVOUS SYSTEM Novel Therapeutic Options for Neuroprotection ERYTHROPOIETIN AND THE NERVOUS SYSTEM
Erythropoietin (EPO) is a glycoprotein hormone, which is produced in kidney and Hver, and is mainly involved in regulating proliferation and maturation of red blood cells. EPO gene expression is induced by hypoxia through the transcription factor hypoxia inducible factor-1, which has been found to be the main regulator of oxygen homeostasis in the body. Suppression of apoptosis is the principle...
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ژورنال
عنوان ژورنال: Clinics in Perinatology
سال: 2015
ISSN: 0095-5108
DOI: 10.1016/j.clp.2015.04.004